BACKGROUND Gastroesophageal reflux disease (GERD) was suggested to be associated with exacerbations of chronic obstructive pulmonary disease (COPD) in recent years. The aim of this study was to examine the association between GERD and COPD exacerbation through a meta-analysis. METHODS Databases including EMBASE, MEDLINE, and the Cochrane Central Register of Controlled Trials were searched with a systematic searching strategy for original articles, published until Jan 2019, without language restriction. RESULTS A total of 13,245 patients from 10 observational articles were included in the meta-analysis. The meta-analysis indicated that GERD is associated with increased risk of COPD exacerbation (OR: 5.37; 95% CI 2.71-10.64). Patients with COPD and GERD had increased number of exacerbation (WMD: 0.48; 95% CI: 0.31 to 0.65). CONCLUSIONS The meta-analysis showed that there was a significant correlation between GERD and COPD exacerbation.

中文翻译：

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对胃食管反流病和慢性阻塞性肺疾病加重进行荟萃分析的系统评价。

背景技术近年来，有人提出胃食管反流病（GERD）与慢性阻塞性肺疾病（COPD）恶化有关。这项研究的目的是通过荟萃分析检查GERD与COPD恶化之间的关系。方法使用系统的搜索策略搜索包括EMBASE，MEDLINE和对照试验的Cochrane中央注册簿在内的原始文章，该文章在2019年1月之前一直发布，没有语言限制。结果该荟萃分析纳入了来自10篇观察性文章的13245例患者。荟萃分析表明，GERD与COPD恶化风险增加相关（OR：5.37； 95％CI 2.71-10.64）。患有COPD和GERD的患者加重次数增加（WMD：0.48; 95％CI：0.31至0.65）。