BACKGROUND The concentrations of cytokines in the aqueous humor from neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) may vary. The study was conducted to compare various cytokine levels in the aqueous humor of eyes with PCV, nAMD and control. METHODS The present case control study included 49 treatment-naïve eyes from 49 patients (PCV 24, nAMD 11, and cataract 14 eyes). Totally 34 angiogenic and inflammatory cytokines in the aqueous humor were measured by Luminex bead-based multiplex array. RESULTS After adjusting for gender and age by multivariate logistic analysis, concentrations of IL-31, LIF, SDF1-α, VEGF-A, VEGF-D were significantly higher in eyes with nAMD or PCV compared with control eyes (all P < 0.05, times in nAMD: 59.5, 6.0, 7.0, 4.5, 5.6, respectively, times in PCV: 51.9, 5.21, 6.6, 4.0, 5.1, respectively), and concentrations of HGF, IP-10, MCP-1, IL-13 were significantly lower in eyes with nAMD or PCV than in control eyes (all P < 0.05, times in nAMD: 2.6, 2.0, 4.5, 4.7, respectively, times in PCV: 1.9, 3.0, 3.0, 2.8, respectively), but none of the 34 cytokines, including VEGF and IL-8, showed significantly different between eyes with nAMD and PCV. CONCLUSIONS Various cytokines involved in inflammation and angiogenesis including elevated IL-31, LIF, SDF1-α, VEGF-A, VEGF-D might be involved in the pathogenesis of nAMD or PCV. None of the 34 cytokines may help to differentiate nAMD and PCV.

中文翻译：

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息肉样脉络膜血管病和新血管性年龄相关性黄斑变性患者房水中细胞因子水平的比较。

背景技术新血管性年龄相关性黄斑变性（nAMD）和息肉样脉络膜脉管炎（PCV）引起的房水中细胞因子的浓度可能会有所不同。进行该研究以比较PCV，nAMD和对照的眼房水中各种细胞因子水平。方法本病例对照研究包括49例未经治疗的49眼（PCV 24，nAMD 11和白内障14眼）。通过Luminex珠基多重阵列测量房水中总共34种血管生成和炎性细胞因子。结果在通过多因素Logistic分析调整性别和年龄后，nAMD或PCV眼的IL-31，LIF，SDF1-α，VEGF-A，VEGF-D的浓度均显着高于对照组（所有P <0.05，在nAMD中的倍数分别为59.5、6.0、7.0、4.5、5.6，在PCV中的倍数为51.9、5.21、6.6，使用nAMD或PCV的眼睛的HGF，IP-10，MCP-1，IL-13的浓度分别显着低于对照组（分别为P <0.05，nAMD的2.6、2.0， PCV的时间分别为4.5、4.7、1.9、3.0、3.0、2.8），但使用nAMD和PCV的两眼之间，包括VEGF和IL-8在内的34种细胞因子均无显着差异。结论与炎症和血管生成有关的多种细胞因子，包括升高的IL-31，LIF，SDF1-α，VEGF-A，VEGF-D，可能与nAMD或PCV的发病有关。34种细胞因子均不能帮助区分nAMD和PCV。nAMD和PCV的眼睛之间，分别有2.8个），但34种细胞因子（包括VEGF和IL-8）中没有一个显示出显着差异。结论与炎症和血管生成有关的多种细胞因子，包括升高的IL-31，LIF，SDF1-α，VEGF-A，VEGF-D，可能与nAMD或PCV的发病有关。34种细胞因子均不能帮助区分nAMD和PCV。nAMD和PCV的眼睛之间，分别有2.8个），但34种细胞因子（包括VEGF和IL-8）中没有一个显示出显着差异。结论与炎症和血管生成有关的多种细胞因子，包括升高的IL-31，LIF，SDF1-α，VEGF-A，VEGF-D，可能与nAMD或PCV的发病有关。34种细胞因子均不能帮助区分nAMD和PCV。