C−C bond activation has emerged as an increasingly useful approach for constructing complex molecular scaffolds through unusual bond-disconnection strategies. As a common versatile functional group, ketones provide an excellent handle and platform for C−C bond activation reactions. Utilizing strain-release, carbon-monoxide-extrusion, and directing-group (DG) approaches, diverse transformations of various ketones have been developed in the past few decades through cleavage of their α C−C bonds. This review highlights the development of C−C bond-activation strategies for both strained and less strained ketones with a focus on transition-metal (TM)-catalyzed approaches.

C-C键激活已成为一种通过不寻常的键断开策略构建复杂分子支架的日益有用的方法。作为常见的多功能官能团，酮为CC键活化反应提供了出色的操作和平台。在过去的几十年中，通过释放应变，一氧化碳挤出和导向基团（DG）的方法，通过裂解αC-C键，已开发出各种酮的多种转化形式。这篇综述着重介绍了针对应变酮和较少应变酮的C-C键活化策略的发展，重点是过渡金属（TM）催化的方法。