In this issue of Neuron, Joffe et al. (2020) assess the antidepressant-relevant effects and underlying neural mechanisms of negative allosteric modulators selective for either metabotropic glutamate receptors 2 (mGlu2) or 3 (mGlu3). Negative modulation of both receptors enhanced excitatory glutamatergic input to mouse prefrontal cortex pyramidal cells, leading to antidepressant-relevant actions.

中文翻译：

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II组mGlu受体特异性负变构调节剂的抗抑郁作用及其机理。

在本期《神经元》中，乔夫等人。（2020）评估对代谢型谷氨酸受体2（mGlu2）或3（mGlu3）选择性的负变构调节剂的抗抑郁相关作用和潜在的神经机制。两种受体的负调节增强了对小鼠前额叶皮层锥体细胞的兴奋性谷氨酸能输入，从而导致了抗抑郁药相关的作用。