Silver (Ag(i)) binding to consensus zinc fingers (ZFs) causes Zn(ii) release inducing a gradual disruption of the hydrophobic core, followed by an overall conformational change and formation of highly stable AgnSn clusters. A compact eight-membered Ag4S4 structure formed by a CCCC ZF is the first cluster example reported for a single biological molecule. Ag(i)-induced conformational changes of ZFs can, as a consequence, affect transcriptional regulation and other cellular processes.

中文翻译：

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锌指中高度稳定的多核AgnSn簇的形成破坏了它们的结构和功能。

与共有锌指（ZFs）结合的银（Ag（i））导致Zn（ii）释放，导致疏水核的逐渐破坏，随后是整体构象变化，并形成了高度稳定的AgnSn簇。由CCCC ZF形成的紧凑的八元Ag4S4结构是报道的单个生物分子的第一个簇示例。Ag（i）诱导的ZF构象变化可能会影响转录调控和其他细胞过程。