当前位置: X-MOL 学术Chem. Sci. › 论文详情
Tri-functional platform for construction of modular antibody fragments for in vivo18F-PET or NIRF molecular imaging
Chemical Science ( IF 9.346 ) Pub Date : 2020/01/07 , DOI: 10.1039/c9sc05007h
Raymond F. Gamache; Kirstin A. Zettlitz; Wen-Ting K. Tsai; Jeffrey Collins; Anna M. Wu; Jennifer M. Murphy

Positron emission tomography (PET) molecular imaging is a powerful tool for interrogating physiological and biochemical processes to understand the biology of disease and advance therapeutic developments. Near-infrared fluorescence (NIRF) optical imaging has become increasingly popular for intraoperative staging to enable cellular resolution imaging of tumor margins during surgical resection. In addition, engineered antibody fragments have emerged as promising molecular imaging agents given their exquisite target selectivity, rapid systemic clearance and site-selective chemical modification. We report a tri-functional platform for construction of a modular antibody fragment that can rapidly be labeled with radionuclides or fluorophores for PET or NIRF molecular imaging of prostate stem cell antigen (PSCA).
更新日期:2020-02-19

 

全部期刊列表>>
欢迎访问IOP中国网站
自然职场线上招聘会
GIANT
产业、创新与基础设施
自然科研线上培训服务
材料学研究精选
胸腔和胸部成像专题
屿渡论文,编辑服务
何川
苏昭铭
陈刚
姜涛
李闯创
李刚
北大
隐藏1h前已浏览文章
课题组网站
新版X-MOL期刊搜索和高级搜索功能介绍
ACS材料视界
天合科研
x-mol收录
上海纽约大学
张健
陈芬儿
厦门大学
史大永
吉林大学
卓春祥
张昊
杨中悦
试剂库存
down
wechat
bug