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Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration.
Nature Reviews Neuroscience ( IF 34.7 ) Pub Date : 2020-01-08 , DOI: 10.1038/s41583-019-0255-9
John V Pluvinage 1, 2 , Tony Wyss-Coray 3, 4, 5, 6
Affiliation  

A rapidly ageing population and a limited therapeutic toolbox urgently necessitate new approaches to treat neurodegenerative diseases. Brain ageing, the key risk factor for neurodegeneration, involves complex cellular and molecular processes that eventually result in cognitive decline. Although cell-intrinsic defects in neurons and glia may partially explain this decline, cell-extrinsic changes in the systemic environment, mediated by blood, have recently been shown to contribute to brain dysfunction with age. Here, we review the current understanding of how systemic factors mediate brain ageing, how these factors are regulated and how we can translate these findings into therapies for neurodegenerative diseases.

中文翻译:

全身因素作为大脑稳态、衰老和神经变性的介质。

人口迅速老龄化和有限的治疗工具箱迫切需要新的方法来治疗神经退行性疾病。脑老化是神经变性的主要危险因素,涉及复杂的细胞和分子过程,最终导致认知能力下降。尽管神经元和神经胶质细胞的细胞内在缺陷可能部分解释了这种下降,但最近已证明由血液介导的系统环境中的细胞外在变化会导致随着年龄的增长而导致脑功能障碍。在这里,我们回顾了目前对系统性因素如何介导大脑衰老、这些因素如何受到调节以及我们如何将这些发现转化为神经退行性疾病疗法的理解。
更新日期:2020-01-08
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