A new model for studying T-cell exhaustion in human cells has enabled scientists to discover a transcription factor that, when overexpressed, helps make chimeric antigen receptor T cells resistant to this mechanism of immune failure. A separate team has found that deleting a key phosphatase improved the antitumor function of engineered T cells as well.

中文翻译：

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下一代CAR T细胞抵抗疲劳。

研究人类细胞中T细胞衰竭的一种新模型使科学家能够发现一种转录因子，当其过度表达时，它有助于使嵌合抗原受体T细胞抵抗这种免疫失败机制。另一个研究小组发现，删除关键的磷酸酶也可以改善工程化T细胞的抗肿瘤功能。