A simple and ubiquitously present group, free amine, is used as a directing group to synthesize axially chiral biaryl compounds by PdII -catalyzed atroposelective C-H olefination. A broad range of axially chiral biaryl-2-amines can be obtained in good yields with high enantioselectivities (up to 97 % ee). Chiral spiro phosphoric acid (SPA) proved to be an efficient ligand and the loading could be reduced to 1 mol % without erosion of enantiocontrol in gram-scale synthesis. The resulting axially chiral biaryl-2-amines also provide a platform for the synthesis of a set of chiral ligands.

中文翻译：

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PdII催化的游离胺导向的Atroposelective CH Olefination合成轴向手性联芳基-2-胺。

一个简单且普遍存在的基团，即游离胺，被用作通过PdII催化的对映选择性CH烯化反应合成轴向手性联芳基化合物的导向基团。可以以高收率和高对映选择性（高达97％ee）获得多种轴向手性联芳基-2-胺。手性螺环磷酸（SPA）被证明是一种有效的配体，在克级合成中，对映体的控制不会降低其负载量至1 mol％。所得的轴向手性联芳基-2-胺也为合成一组手性配体提供了平台。