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Modification of miRNA Expression through plant extracts and compounds against breast cancer: Mechanism and translational significance.
Phytomedicine ( IF 7.9 ) Pub Date : 2020-01-08 , DOI: 10.1016/j.phymed.2020.153168
Fayyaz Ahmed 1 , Bushra Ijaz 1 , Zarnab Ahmad 1 , Nadia Farooq 2 , Muhammad Bilal Sarwar 1 , Tayyab Husnain 1
Affiliation  

BACKGROUND Cancer is hyper-proliferative, multi-factorial and multi-step, heterogeneous group of molecular disorders. It is the second most reported disease after heart diseases. Breast carcinoma is the foremost death causing disease in female population worldwide. Cancer can be controlled by regulating the gene expression. Current therapeutic options are associated with severe side effects and are expensive for the people living in under-developed countries. Plant derived substances have potential application against different diseases like cancer, inflammation and viral infections. HYPOTHESIS The mechanism of action of the medicinal plants is largely unknown. Targeting gene network and miRNA using medicinal plants could help in improving the therapeutic options against cancer. METHODS The literature from 135 articles was reviewed by using PubMed, google scholar, Science direct to find out the plants and plant-based compounds against breast cancer and also the studies reporting their mechanistic route of action both at coding and noncoding RNA levels. RESULTS Natural products act as selective inhibitors of the cancerous cells by targeting oncogenes and tumor suppressor genes or altering miRNA expression. Natural compounds like EGCG from tea, Genistein from fava beans, curcumin from turmeric, DIM found in cruciferous, Resveratrol a polyphenol and Quercetin a flavonoid is found in various plants have been studied for their anticancer activity. The EGCG was found to inhibit proliferative activity by modulating miR-16 and miR-21. Similarly, DIM was found to down regulate miR-92a which results to modulate NFkB and stops cancer development. Another plant-based compound Glyceollins found to upregulate miR-181c and miR-181d having role in tumor suppression. It also found to regulate miR-22, 29b and c, miR-30d, 34a and 195. Quercetin having anti-cancer activity induce the apoptosis through regulating miR-16, 26b, 34a, let-7g, 125a and miR-605 and reduce the miRNA expression like miR-146a/b, 503 and 194 which are involved in metastasis. CONCLUSION Targeting miRNA expression using natural plant extracts can have a reverse effect on cell proliferation; turning on and off tumor-inducing and suppressing genes. It can be efficiently adopted as an adjuvant with the conventional form of therapies to increase their efficacy against cancer progression.

中文翻译:

通过植物提取物和化合物对抗乳腺癌的miRNA表达修饰:机制和翻译意义。

背景技术癌症是过度增生,多因素和多步骤,分子疾病的异质性群体。它是仅次于心脏病的第二大疾病。乳腺癌是导致全球女性人群死亡的最主要疾病。可以通过调节基因表达来控制癌症。当前的治疗选择伴随着严重的副作用,并且对于生活在不发达国家的人们来说是昂贵的。植物来源的物质具有潜在的用途,可用于治疗多种疾病,例如癌症,炎症和病毒感染。假设药用植物的作用机理在很大程度上尚不清楚。使用药用植物靶向基因网络和miRNA可以帮助改善针对癌症的治疗选择。方法使用publish,google学者,Science直接审查了135篇文章中的文献,以找出抗乳腺癌的植物和植物基化合物,并研究了其在编码和非编码RNA水平上的作用机理。结果天然产物通过靶向癌基因和肿瘤抑制基因或改变miRNA表达而充当癌细胞的选择性抑制剂。已经研究了天然化合物,例如茶中的EGCG,蚕豆中的染料木黄酮,姜黄中的姜黄素,十字花科中发现的DIM,白藜芦醇中的多酚和槲皮素中的黄酮类化合物的抗癌活性。发现EGCG通过调节miR-16和miR-21抑制增殖活性。同样,发现DIM下调miR-92a,从而调节NFkB并阻止癌症的发展。发现另一种基于植物的化合物糖脂可上调miR-181c和miR-181d在抑制肿瘤中的作用。还发现其调节miR-22、29b和c,miR-30d,34a和195。具有抗癌活性的槲皮素通过调节miR-16、26b,34a,let-7g,125a和miR-605和miR诱导凋亡。减少与转移有关的miRNA表达,例如miR-146a / b,503和194。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。发现另一种基于植物的化合物糖脂可上调miR-181c和miR-181d在抑制肿瘤中的作用。还发现其调节miR-22、29b和c,miR-30d,34a和195。具有抗癌活性的槲皮素通过调节miR-16、26b,34a,let-7g,125a和miR-605和miR诱导凋亡。减少与转移有关的miRNA表达,例如miR-146a / b,503和194。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。发现另一种基于植物的化合物糖脂可上调miR-181c和miR-181d在抑制肿瘤中的作用。还发现其调节miR-22、29b和c,miR-30d,34a和195。具有抗癌活性的槲皮素通过调节miR-16、26b,34a,let-7g,125a和miR-605和miR诱导凋亡。减少与转移有关的miRNA表达,例如miR-146a / b,503和194。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。34a和195。具有抗癌活性的槲皮素通过调节miR-16、26b,34a,let-7g,125a和miR-605诱导凋亡,并降低涉及的miRNA像miR-146a / b,503和194。在转移中。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。34a和195。具有抗癌活性的槲皮素通过调节miR-16、26b,34a,let-7g,125a和miR-605诱导凋亡,并降低涉及的miRNA像miR-146a / b,503和194。在转移中。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。结论使用天然植物提取物靶向miRNA表达可对细胞增殖产生逆向作用。打开和关闭肿瘤诱导和抑制基因。可以有效地将其作为常规疗法的佐剂,以提高其对抗癌症进展的功效。
更新日期:2020-01-08
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