OBJECTIVES The present research aimed to explore the effect of a mucoadhesive containing Jasminum grandiflorum leaves on the process of oral wound healing in animal samples. MATERIALS AND METHODS The present double-blinded research was conducted on animals. To this aim, 28 rats were randomly selected and assigned to groups of control and experiment. The lesion was created by punch no. 3 in the midline of the mandibular labial mucosa of all mice. Each group received either a medicine or a placebo exclusively coded. The extent of contraction and wound healing was clinically assessed. To compare the two research groups, chi-squared test, repeated-measure ANOVA, and Mann-Whitney U test were run. SPSS software was used to do the statistical analyses. RESULTS Statistically significant differences were found between the percentage of wound contraction on the 3rd day (40.91% vs. 16.5%, p = 0.04) and the 7th day (92.9% vs. 69.2%, p = 0.05), wound recovery (57.1% vs. 21.4%, p = 0.05) and degree of inflammation on the 7th day (p = 0.00), type (p = 0.04) and thickness of epithelium (p = 0.00) and type of connective tissue (p = 0.00) on the 14th day. CONCLUSION Investigations showed that the drug was more effective than the placebo in accelerating wound healing in clinical and histopathological terms. CLINICAL RELEVANCE Accelerating wound healing in dental treatments and oral ulcers can also affect the quality of life of individuals.

中文翻译：

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含有黏膜黏附剂的茉莉花的配方及其对口腔活检溃疡愈合效果的评估。

目的本研究旨在探讨含有茉莉茉莉叶的粘膜粘附剂对动物样品口腔伤口愈合过程的影响。材料与方法目前对动物进行了双盲研究。为了这个目的，随机选择28只大鼠，并分为对照组和实验组。病变是由打孔器编号造成的。在所有小鼠的下颌唇粘膜中线3。每个组接受专门编码的药物或安慰剂。临床评估了收缩和伤口愈合的程度。为了比较两个研究组，进行了卡方检验，重复测量方差分析和曼惠特尼U检验。使用SPSS软件进行统计分析。结果在第3天和第7天伤口收缩率（57.1％）之间的差异有统计学意义（40.91％vs. 16.5％，p = 0.04）和第7天（92.9％vs. 69.2％，p = 0.05）对比21.4％，p = 0.05）和第7天的炎症程度（p = 0.00），类型（p = 0.04）和上皮厚度（p = 0.00）和结缔组织类型（p = 0.00）第14天。结论研究表明，在临床和组织病理学方面，该药物在促进伤口愈合方面比安慰剂更有效。临床相关性牙科治疗和口腔溃疡中伤口愈合的加快也可能影响个体的生活质量。05）和第7天的炎症程度（p = 0.00），第14天的类型（p = 0.04）和上皮厚度（p = 0.00）和结缔组织的类型（p = 0.00）。结论研究表明，在临床和组织病理学方面，该药物在促进伤口愈合方面比安慰剂更有效。临床相关性牙科治疗和口腔溃疡中伤口愈合的加快也可能影响个体的生活质量。05）和第7天的炎症程度（p = 0.00），第14天的类型（p = 0.04）和上皮厚度（p = 0.00）和结缔组织的类型（p = 0.00）。结论研究表明，在临床和组织病理学方面，该药物在促进伤口愈合方面比安慰剂更有效。临床相关性牙齿治疗和口腔溃疡中伤口愈合的加快也可能影响个体的生活质量。