INTRODUCTION Abdominal pain is a cardinal feature of irritable bowel syndrome (IBS); however, differences in abdominal pain among IBS subtypes remain unknown. We aimed to characterize abdominal pain symptoms among established IBS subtypes using data from the National Gastrointestinal (GI) Survey. METHODS Individuals participating in the National GI Survey completed National Institutes of Health GI Patient-Reported Outcomes Measurement Information System (GI-PROMIS) questionnaires. Adults meeting modified Rome III IBS criteria and reporting abdominal pain in the previous 7 days were eligible. Outcomes included abdominal pain severity, bothersomeness, interference with daily activities, frequency, and location. Results were stratified by subtype (diarrhea [IBS-D], constipation [IBS-C], and mixed [IBS-M]). Regression models adjusted for demographics and comorbidities. RESULTS One thousand one hundred fifty-eight individuals (245 IBS-D, 232 IBS-C, and 681 IBS-M) with active IBS symptoms (defined as abdominal pain in the past 7 days) were included. Demographics were similar among the subtypes except for age, race/ethnicity, education, and marital status. The GI-PROMIS score was lower for IBS-D (percentile score of 68.6, SD = 25.1; P = 0.001) and IBS-M (69.1, SD = 25.1; P < 0.001) compared with IBS-C (75.5, SD = 20.7). Abdominal pain was more bothersome (P = 0.001), caused more interference with daily activities (P = 0.03), and was more frequent (P = 0.047) for individuals with IBS-C compared with individuals with IBS-D. No differences in these domains were seen between individuals with IBS-D and IBS-M. Individuals with IBS-C and IBS-M had more widespread pain compared with those with IBS-D. DISCUSSION In this population-based study, we found that abdominal pain characteristics differ between the IBS subtypes. Namely, individuals with IBS-C experience more bothersome, frequent, and diffuse abdominal pain compared with those with IBS-D.

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腹痛的表现和特征因肠易激综合征亚型而异：基于全国人群的研究结果。

引言 腹痛是肠易激综合征 (IBS) 的主要特征。然而，IBS 亚型之间腹痛的差异仍然未知。我们旨在使用来自全国胃肠道 (GI) 调查的数据来描述已建立的 IBS 亚型中的腹痛症状。方法 参与国家胃肠道调查的个人完成了美国国立卫生研究院胃肠道患者报告的结果测量信息系统 (GI-PROMIS) 问卷调查。符合修订的罗马 III IBS 标准并在过去 7 天内报告腹痛的成人符合条件。结果包括腹痛的严重程度、烦人程度、对日常活动的干扰、频率和位置。结果按亚型（腹泻[IBS-D]、便秘[IBS-C]和混合型[IBS-M]）分层。针对人口统计和合并症调整的回归模型。结果 纳入了 1158 名具有活动性 IBS 症状（定义为过去 7 天的腹痛）的个体（245 名 IBS-D、232 名 IBS-C 和 681 名 IBS-M）。除年龄、种族/民族、教育和婚姻状况外，各亚型的人口统计特征相似。与 IBS-C（75.5，SD = 20.7)。与 IBS-D 患者相比，IBS-C 患者的腹痛更令人烦恼（P = 0.001），对日常活动造成更多干扰（P = 0.03），并且更频繁（P = 0.047）。在 IBS-D 和 IBS-M 个体之间没有发现这些领域的差异。与 IBS-D 患者相比，IBS-C 和 IBS-M 患者的疼痛更为广泛。讨论 在这项基于人群的研究中，我们发现 IBS 亚型之间的腹痛特征不同。也就是说，与 IBS-D 患者相比，IBS-C 患者的腹痛更烦人、更频繁和弥漫性腹痛。