CO-releasing molecules (CORMs) have been widely studied for their anti-inflammatory, antiapoptotic, and antiproliferative effects. CORM-3 is a water-soluble Ru-based metal carbonyl complex, which metallates serum proteins and readily releases CO in biological media. In this work, we evaluated the anti-inflammatory and wound-healing effects of gold nanoparticles–CORM-3 conjugates, [email protected]@BSA·Ru(CO)_x, exploring its use as an efficient CO carrier. Our results suggest that the nanoformulation was capable of inducing a more pronounced cell effect, at the anti-inflammatory level and a faster tissue repair, probably derived from a rapid cell uptake of the nanoformulation that results in the increase of CO inside the cell.

中文翻译：

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通过金纳米粒子矢量化的CO释放分子改善抗炎反应。

释放CO的分子（CORM）具有抗炎，抗凋亡和抗增殖的作用，因此已被广泛研究。CORM-3是一种水溶性的Ru基羰基金属配合物，可金属化血清蛋白并在生物介质中轻松释放CO。在这项工作中，我们评估了金纳米粒子–CORM-3偶联物[email protected] @ BSA·Ru（CO）_x的抗炎和伤口愈合作用，探索了其作为有效的CO载体的用途。我们的结果表明，纳米制剂能够在抗炎水平和更快的组织修复中诱导更明显的细胞效应，这可能是由于纳米制剂对细胞的快速摄取导致了细胞内CO的增加。