The development of upconversion nanoparticles based logic systems, especially integrated logic systems is still a challenge until now. In this work, an upconversion nanocomposite system is developed and studied for the sensing abilities toward hydrion, hydroxyl ions, metal ions and anions (S2-, I-) by taking the advantages of turn-on and turn-off upconversion fluorescence switching response. Triggering by different kinds of ions, the upconversion system can act as a fluorescence switch due to the specific recognition abilities of Rhodamine 6G functionalized PEI for specific ions and the energy transfer process from upconversion nanoparticles to recognition molecules. Based on these results, multiple molecular logic gates, including single-input logic operation (YES, NOT), double-inputs logic operation (OR, AND, NOR, INHIBIT) and multiple-input integrative logic operation (INHIBIT+OR) are developed by employing hydrion, hydroxyl ions, metal ions and anions as inputs and the changes in the upconversion fluorescence intensity as output. The multiple logic operations are of great significance for the applications in biomedicine and molecular calculation.

中文翻译：

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基于化学触发的上转换荧光切换的多种逻辑运算。

迄今为止，基于上转换纳米颗粒的逻辑系统，特别是集成逻辑系统的开发仍然是一个挑战。在这项工作中，通过利用开启和关闭上转换荧光转换响应的优势，开发并研究了上转换纳米复合材料系统对氢离子，氢氧根离子，金属离子和阴离子（S2-，I-）的传感能力。由于若丹明6G功能化的PEI对特定离子的特定识别能力以及从上转换纳米粒子到识别分子的能量转移过程，上转换系统可以触发不同种类的离子，从而起到荧光开关的作用。根据这些结果，多个分子逻辑门包括单输入逻辑运算（是，非），双输入逻辑运算（或，与，或非，INHIBIT）和多输入积分逻辑运算（INHIBIT + OR）是通过使用氢离子，氢氧根离子，金属离子和阴离子作为输入并输出上转换荧光强度的变化来开发的。多种逻辑运算对于生物医学和分子计算中的应用具有重要意义。