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Indoor use of attractive toxic sugar bait in combination with long-lasting insecticidal net against pyrethroid-resistant Anopheles gambiae: an experimental hut trial in Mbé, central Côte d'Ivoire.
Malaria Journal ( IF 3 ) Pub Date : 2020-01-07 , DOI: 10.1186/s12936-019-3095-1
Joanna E C Furnival-Adams 1 , Soromane Camara 2 , Mark Rowland 1 , Alphonsine A Koffi 2 , Ludovic P Ahoua Alou 2 , Welbeck A Oumbouke 1, 2 , Raphael N'Guessan 1, 2
Affiliation  

BACKGROUND Indoor attractive toxic sugar bait (ATSB) has potential as a supplementary vector-control and resistance-management tool, offering an alternative mode of insecticide delivery to current core vector-control interventions, with potential to deliver novel insecticides. Given the high long-lasting insecticidal bed net (LLIN) coverage across Africa, it is crucial that the efficacy of indoor ATSB in combination with LLINs is established before it is considered for wider use in public health. METHODS An experimental hut trial to evaluate the efficacy of indoor ATSB traps treated with 4% boric acid (BA ATSB) or 1% chlorfenapyr (CFP ATSB) in combination with untreated nets or LLINs (holed or intact), took place at the M'bé field station in central Côte d'Ivoire against pyrethroid resistant Anopheles gambiae sensu lato. RESULTS The addition of ATSB to LLINs increased the mortality rates of wild pyrethroid-resistant An. gambiae from 19% with LLIN alone to 28% with added BA ATSB and to 39% with added CFP ATSB (p < 0.001). Anopheles gambiae mortality with combined ATSB and untreated net was similar to that of combined ATSB and LLIN regardless of which insecticide was used in the ATSB. The presence of holes in the LLIN did not significantly affect ATSB-induced An. gambiae mortality. Comparative tests against pyrethroid resistant and susceptible strains using oral application of ATSB treated with pyrethroid demonstrated 66% higher survival rate among pyrethroid-resistant mosquitoes. CONCLUSION Indoor ATSB traps in combination with LLINs enhanced the control of pyrethroid-resistant An. gambiae. However, many host-seeking An. gambiae entering experimental huts with indoor ATSB exited into the verandah trap without sugar feeding when restricted from a host by a LLIN. Although ATSB has potential for making effective use of classes of insecticide otherwise unsuited to vector control, it does not exempt potential selection of resistance via this route.

中文翻译:

在室内使用诱人的有毒糖饵和长效杀虫剂网,可抵御拟除虫菊酯的冈比亚按蚊:在科特迪瓦中部姆贝的一项实验小屋试验。

背景技术室内诱人的有毒糖诱饵(ATSB)具有作为补充的媒介控制和抗药性管理工具的潜力,为当前的核心媒介控制干预措施提供了另一种杀虫剂递送方式,并有可能递送新型杀虫剂。考虑到整个非洲的杀虫剂床网(LLIN)的持久性很高,至关重要的是,在考虑将室内ATSB与LLIN结合使用之前,要先确定其功效,然后再考虑将其广泛用于公共卫生领域。方法在M'进行了一项试验性小屋试验,以评估用4%硼酸(BA ATSB)或1%氯苯那吡(CFP ATSB)结合未经处理的网或LLIN(带孔或完整)处理的室内ATSB捕集阱的功效科特迪瓦中部的bé野外监测站对拟除虫菊酯抗药的冈比亚按蚊(Anopheles)结果向LLINs中添加ATSB可提高野生拟除虫菊酯抗性An的死亡率。冈比亚从单独使用LLIN的19%到添加BA ATSB的28%和添加CFP ATSB的39%(p <0.001)。结合使用ATSB和未处理的网,冈比亚按蚊的死亡率与结合使用ATSB和LLIN的死亡率相似,无论在ATSB中使用哪种杀虫剂。LLIN中孔的存在并未显着影响ATSB诱导的An。冈比亚死亡率。使用拟除虫菊酯处理的ATSB口服应用对拟除虫菊酯抗药性和易感菌株的比较试验表明,在拟除虫菊酯抗性蚊子中存活率提高了66%。结论室内ATSB捕集阱与LLIN结合可增强对拟除虫菊酯抗性An。冈比亚 但是,许多寻求主机的人。当LLIN限制寄主将甘比亚进入带有室内ATSB的实验小屋时,它进入了阳台陷阱,没有糖分。尽管ATSB有潜力有效利用原本不适合病媒控制的各类杀虫剂,但它并不能免除通过这种途径可能产生的抗性选择。
更新日期:2020-01-07
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