Recently, intensive research has been conducted on the development of bacterial repelling surfaces because of the disadvantages of the conventional bactericidal leaching and contact-killing surfaces for practical application. Among these bacteria-repelling methodologies, zwitterionic polymers were widely investigated because of its excellent nonfouling properties, but its durability has limited its widespread use since most of the surfaces were developed by constructing polymer brushes via atom transfer radical polymerization (ATRP). In this study, we developed zwitterionic polymer surfaces with desirable mechanical and chemical durability for long-term use through simple blending of poly(sulfobetaine methacrylate) (PSBMA)/poly(ether sulfone) (PES) semi-interpenetrated networked microgels with hydrophobic PES polymer matrix. Results show that the as-prepared surfaces can efficiently induce hydration layers and, thus, reduce the bacterial attachment through resisting nonspecific protein adsorption. The bacterial adhesion for Escherichia coli and Staphylococcus aureus was investigated under both flow and static conditions. This work has set a paradigm for developing durable antibacterial surfaces with nonfouling properties.

中文翻译：

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联网的两性离子耐用抗菌表面

最近，由于传统的杀菌浸出和接触杀灭表面在实际应用中的缺点，已经对细菌排斥表面的开发进行了深入研究。在这些抗菌方法中，两性离子聚合物因其优异的防污性能而受到广泛研究，但由于大多数表面是通过原子转移自由基聚合 (ATRP) 构建聚合物刷而开发的，因此其耐用性限制了其广泛使用。在这项研究中，我们通过将聚（磺基甜菜碱甲基丙烯酸酯）（PSBMA）/聚（醚砜）（PES）半互穿网络微凝胶与疏水性 PES 聚合物简单混合，开发出具有理想机械和化学耐久性的两性离子聚合物表面，可长期使用。矩阵。结果表明，所制备的表面可以有效地诱导水化层，从而通过抵抗非特异性蛋白质吸附来减少细菌附着。细菌粘附为在流动和静态条件下研究了大肠杆菌和金黄色葡萄球菌。这项工作为开发具有防污性能的耐用抗菌表面树立了典范。