A two-dimensional fluorescent metal-organic framework (MOF) sensor, TMU-5S, was synthesized by introducing rhodamine B into the framework of TMU-5. This dye-sensitized MOF was explored as a ratiometric fluorescent sensor for Ca2+ signaling in the presence of interfering cations in ionic concentrations similar to that of blood plasma that exhibits exceptional sensitivity and selectivity to Ca2+ and faster response and recovery times than any other reported fluorescent sensor. This can be attributed to strong electrostatic interactions between basic azine groups in the narrow pore walls of TMU-5S and Ca2+ as hard-hard acid-base interactions. The results show that the two-dimensional signal transduction can reduce interfering responses from the environment and thus create exceptional sensitivity.

中文翻译：

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用于人体血液离子浓度介质中钙信号传导的灵敏比例荧光金属-有机骨架传感器。

通过将若丹明B引入TMU-5的框架合成了二维荧光金属-有机框架（MOF）传感器TMU-5S。这种染料敏化的MOF被用作比例荧光传感器，用于Ca2 +信号传导，在存在离子浓度类似于血浆的离子浓度的干扰阳离子的情况下，它对Ca2 +表现出卓越的灵敏度和选择性，并且比任何其他报道的荧光传感器表现出更快的响应和恢复时间。这可以归因于TMU-5S的狭窄孔壁中的碱性嗪基团和Ca2 +之间的强静电相互作用，如硬-硬酸-碱相互作用。结果表明，二维信号转导可以减少来自环境的干扰响应，从而产生出色的灵敏度。