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Epidemiological evidence for associations between variants in microRNA or biosynthesis genes and lung cancer risk.
Cancer Medicine ( IF 4 ) Pub Date : 2020-01-07 , DOI: 10.1002/cam4.2645
Guanchu Liu 1 , Jie Tian 2 , Chunjian Zuo 1 , Yufu Li 3 , Kui Fu 4 , Huanwen Chen 1
Affiliation  

In the past decade, the studies involving single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) with lung cancer (LC) risk have been performed, however, these results are inconsistent, and a systematic research synopsis has not been performed yet. Therefore, we attempted to perform comprehensive meta-analyses to assess the relationships between SNPs in miRNAs or biosynthesis genes and LC risk and further evaluate the epidemiological credibility of these significant associations. We used PubMed, Medline, and Web of Science to search for relevant articles published before 30 May 2019 that assessed relationships between SNPs in miRNAs or biosynthesis genes and LC risk. The cumulative epidemiological evidence of statistical relationships was further assessed combining Venice Criteria and a false-positive report probability test. Based on 20 publications with 15 969 cases and 17 174 controls, we found that six variants in miRNAs or biosynthesis genes that proved significant associations with LC risk, whereas five proved no association. Subgroup analyses by ethnicity and genetic models were performed, suggesting that four associations were rated as demonstrating strong evidence of relationship with LC risk, including miRNA-146a rs2910164 in all populations under dominant model and in Asians under dominant and recessive models, and AGO1 rs595961 in Asians under allelic model. Three associations were graded as moderate, and seven associations were rated as weak. This study presents the relationships between SNPs in miRNAs or biosynthesis genes and LC risk, subsequently demonstrates the credibility of these significant associations, and highlights the role in the pathogenesis of LC.

中文翻译:

microRNA或生物合成基因变异与肺癌风险之间关联的流行病学证据。

在过去的十年中,已经进行了涉及具有肺癌(LC)风险的microRNA(miRNA)中的单核苷酸多态性(SNP)的研究,但是,这些结果不一致,并且尚未进行系统的研究提要。因此,我们试图进行全面的荟萃分析,以评估miRNA或生物合成基因中SNP与LC风险之间的关系,并进一步评估这些重要关联的流行病学可信度。我们使用PubMed,Medline和Web of Science搜索2019年5月30日之前发表的相关文章,以评估miRNA或生物合成基因中SNP与LC风险之间的关系。结合威尼斯标准和假阳性报告概率检验,进一步评估了统计关系的累积流行病学证据。根据20篇有关15 969例病例和17 174例对照的出版物,我们发现miRNA或生物合成基因中有6个变异与LC风险有显着关联,而5个变异与LC风险无显着关联。进行了种族和遗传模型的亚组分析,表明四个协会被评定为与LC风险相关的有力证据,包括在显性模型下的所有人群中以及在显性和隐性模型下的亚洲人中的所有人群中的miRNA-146a rs2910164,以及在显性模型中的AGO1 rs595961。等位基因模型下的亚洲人。三个协会被评为中级,七个协会被评为弱。这项研究提出了miRNA或生物合成基因中的SNP与LC风险之间的关系,随后证明了这些重要关联的可信度,
更新日期:2020-01-07
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