Older adults exposed to periods of inactivity during hospitalization, illness, or injury lose muscle mass and strength. This, in turn, predisposes poor recovery of physical function upon reambulation and represents a significant health risk for older adults. Bed rest (BR) results in altered skeletal muscle fuel metabolism and loss of oxidative capacity that have recently been linked to the muscle atrophy program. Our primary objective was to explore the effects of BR on mitochondrial energetics in muscle from older adults. A secondary objective was to examine the effect of β-hydroxy-β-methylbuturate (HMB) supplementation on mitochondrial energetics.

中文翻译：

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成年人卧床休息10天后，骨骼肌能量和线粒体功能受损。

住院，患病或受伤期间处于不活动状态的老年人失去肌肉质量和力量。反过来，这会导致在重新分配时身体机能恢复较差，并给老年人带来重大的健康风险。卧床休息（BR）导致骨骼肌燃料代谢的改变和氧化能力的丧失，这些作用最近与肌肉萎缩程序有关。我们的主要目的是探讨BR对老年人肌肉线粒体能量的影响。第二个目的是研究补充β-羟基-β-甲基丁酸（HMB）对线粒体能量的影响。