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Prevention of CAR-T-cell dysfunction.
Nature Biomedical Engineering ( IF 28.1 ) Pub Date : 2020-01-01 , DOI: 10.1038/s41551-019-0512-2
Martin W LaFleur 1, 2, 3 , Brian C Miller 1, 2, 3, 4 , Arlene H Sharpe 1, 2, 3
Affiliation  

The overexpression of the transcription factor c-Jun improves chimeric-antigen-receptor T-cell functionality and enhances the killing of low-antigen-expressing liquid and solid cancers in mice.

中文翻译:

预防CAR-T细胞功能障碍。

转录因子c-Jun的过度表达改善了嵌合抗原受体T细胞的功能,并增强了小鼠中低抗原表达的液体和固体癌症的杀伤力。
更新日期:2020-01-07
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