In this paper, a high‐sensitivity electrochemical sensor based on platinum (Pt) doped nickel oxide (NiO) nanoparticles and multi‐walled carbon nanotubes (MWCNTs) modified glassy carbon electrode (Pt−NiO/MWCNTs/GCE) has been developed to determine piroxicam (PIR) and amlodipine (AML) simultaneously. The electrochemical behavior of PIR and AML at the proposed sensor has been investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. Pt doped NiO nanoparticles were synthesized by the sol‐gel procedure and were investigated using X‐ray diffraction (XRD), energy dispersive X‐ray spectroscopy (EDX) and field emission scanning electron microscopy (FESEM) techniques. DPV responses of PIR and AML increased linearly with their concentration in wide linear dynamic ranges of 0.6–320.0 μM and 1.0–250.0 μM, respectively. The limits of detection were 0.061 μM for PIR and 0.092 μM for AML. The excellent analytical figure of merits of the proposed modified electrode leads to application of it promising electrochemical sensor to determine PIR and AML in human serum and urine with satisfactory results.

中文翻译：

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基于Pt掺杂的NiO纳米颗粒/ MWCNTs纳米复合修饰电极的高灵敏电化学传感器，用于同时感测吡罗昔康和氨氯地平

本文开发了一种基于铂（Pt）掺杂的氧化镍（NiO）纳米颗粒和多壁碳纳米管（MWCNTs）修饰的玻碳电极（Pt-NiO / MWCNTs / GCE）的高灵敏度电化学传感器，以确定吡罗昔康（PIR）和氨氯地平（AML）同时使用。通过循环伏安法（CV），差分脉冲伏安法（DPV）和计时电流法（CA）方法研究了PIR和AML在所提出的传感器上的电化学行为。Pt掺杂的NiO纳米粒子通过溶胶-凝胶法合成，并使用X射线衍射（XRD），能量色散X射线光谱（EDX）和场发射扫描电子显微镜（FESEM）技术进行了研究。PIR和AML的DPV响应在0.6–320.0μM和1.0–250.0μM的宽线性动态范围内随着其浓度线性增加，分别。PIR检测限为0.061μM，AML检测限为0.092μM。所提出的修饰电极的优异的分析品质优劣导致其在有希望的电化学传感器用于测定人血清和尿液中的PIR和AML方面具有令人满意的结果。