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Generation of a hiPSC line ZZUNEUi007-A from a patient with hypertrophic cardiomyopathy caused by mutation in MYH7.
Stem Cell Research ( IF 1.2 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.scr.2020.101699 Xiaowei Li 1 , Yangyang Liu 1 , Feifei Liu 2 , Xiaojuan Wang 3 , Mengduan Liu 1 , Wenting Du 1 , Jing Zhao 1 , Mengyu Wang 1 , Liang Hu 1 , Chuchu Wang 4 , Wanrong Fu 1 , Jianzeng Dong 5 , Xiaoyan Zhao 1
中文翻译：
由MYH7突变引起的肥厚型心肌病患者产生hiPSC系ZZUNEUi007-A。
更新日期：2020-01-07
Stem Cell Research ( IF 1.2 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.scr.2020.101699 Xiaowei Li 1 , Yangyang Liu 1 , Feifei Liu 2 , Xiaojuan Wang 3 , Mengduan Liu 1 , Wenting Du 1 , Jing Zhao 1 , Mengyu Wang 1 , Liang Hu 1 , Chuchu Wang 4 , Wanrong Fu 1 , Jianzeng Dong 5 , Xiaoyan Zhao 1
Affiliation
Hypertrophic cardiomyopathy (HCM) is the most common monogenic cardiovascular disorder. In this study, we generated human induced pluripotent stem cells (iPSC) ZZUNEUi007-A from dermal fibroblasts of an HCM patient with the p. R663H (c. 1988 G > A) mutation in MYH7. The generated hiPSC line had normal karyotype, showed robust expression of pluripotency markers and could differentiate into all three germ layers in vivo.
中文翻译：
由MYH7突变引起的肥厚型心肌病患者产生hiPSC系ZZUNEUi007-A。
肥厚型心肌病（HCM）是最常见的单基因心血管疾病。在这项研究中，我们从HCM患者的皮肤成纤维细胞中产生了人诱导的多能干细胞（iPSC）ZZUNEUi007-A。MYH7中的R663H（c。1988 G > A）突变。产生的hiPSC品系具有正常的核型，显示了多能性标记物的稳定表达，并且可以在体内分化为所有三个胚层。
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