DNA-protein crosslinks represent a severe kind of DNA damage as they disturb essential processes like transcription and DNA replication, due to their bulkiness. To ensure the maintenance of genome integrity, it is necessary for all living organisms to repair these lesions in a timely manner. Over the last years, much knowledge has been obtained regarding the repair of DNA-protein crosslinks (DPCs), however it was only recently that the first insights into the mechanisms of DPC repair in plants were observed. The plant DPC network consists of at least three parallel pathways that resolve DPCs in distinct biochemical ways. The endonuclease MUS81 resolves the DPC by cleaving the DNA part of the crosslink, the protease WSS1A is able to degrade the protein part and the tyrosyl-DNA-phosphodiesterase TDP1 can hydrolyse the crosslink between a protein and the DNA. However, due to the variety of different DPC types and the evolutionary conservation of pathways between eukaryotes, we expect that future research will reveal additional factors involved in DPC repair in plants.

DNA-蛋白质交联由于其体积大，会干扰诸如转录和DNA复制之类的基本过程，因此是一种严重的DNA损伤。为了确保维持基因组完整性，所有活生物体都必须及时修复这些病变。在过去的几年中，已经获得了许多有关DNA-蛋白质交联（DPC）修复的知识，但是直到最近才对植物中DPC修复机理有了首次见识。植物DPC网络由至少三个并行途径组成，这些途径以独特的生化方式分解DPC。内切核酸酶MUS81通过切割交联的DNA部分来解析DPC，蛋白酶WSS1A能够降解蛋白质部分，酪氨酰DNA磷酸二酯酶TDP1可以水解蛋白质与DNA之间的交联。但是，由于不同DPC类型的多样性以及真核生物之间途径的进化保守性，我们希望未来的研究将揭示涉及植物DPC修复的其他因素。