Drug self-delivery systems (DSDSs) have attracted intense attention due to their high drug content. However, their practical application still suffers from their premature drug leakage, slow drug release, and/or low antitumor efficacy of the released small molecular drugs. Here, acid-labile poly(Doxazolidine) (P(Doxaz)) is designed as a polyprodrug for the self-delivery of high antitumor chemotherapeutics (Doxazolidine (Doxaz)), with an ultrahigh Doxaz content of 92.45%. The P(Doxaz) nanoparticles could completely degrade into Doxaz within 10 h in the simulated tumor intracellular microenvironment, with a low drug leakage of 12.9% over 12 h in the normal physiological media. Owing to the ultrahigh drug content, fast acid-triggered degradation and drug release, and high antitumor efficacy of Doxaz, the proposed DSDS possesses an enhanced antiproliferation efficacy compared to the free DOX, demonstrating its potential in future tumor treatments.

中文翻译：

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酸不稳定的聚（多沙唑烷）作为具有超高药物含量的多药前体的合成，可自行递送高性能化学治疗剂。

药物自传递系统（DSDSs）由于药物含量高而备受关注。然而，它们的实际应用仍然遭受其过早的药物泄漏，药物缓慢的释放和/或所释放的小分子药物的低抗肿瘤功效的困扰。在此，酸不稳定的聚（Doxazolidine）（P（Doxazaz））被设计为一种多药前药，可自我递送高抗肿瘤化疗药物（Doxazolidine（Doxaz）），其超高Doxaz含量为92.45％。在模拟的肿瘤细胞微环境中，P（Doxaz）纳米颗粒可以在10 h内完全降解为Doxaz，在正常生理介质中，在12 h内的药物泄漏率仅为12.9％。由于Doxaz的药物含量超高，酸引发的快速降解和药物释放以及Doxaz的高抗肿瘤功效，