Supramolecular peptide materials have attracted increasing attention due to their natural biological origin and versatile applications. However, it is often challenging to control and modulate the self-assembly of peptides (especially short peptides) for constructing hydrogels with tunable mechanical properties and adaptive injectability toward biomedical applications. Here, we report a supramolecular strategy for forming robust and injectable hydrogels based on the self-assembly of a rationally designed bola-dipeptide. The self-assembled hydrogels exhibit versatile functionalities, including flow under shear stress, good recovery properties, and easy encapsulation of hydrophilic prodrugs. The prodrug-loaded hydrogels show sustained release profiles, inhibited nontargeted leakage, and enhanced localized prodrug conversion, leading to highly efficient photodynamic tumor ablation. Hence, the supramolecular strategy is promising for the rational construction of injectable hydrogels toward targeted and sustained prodrug conversion and tumor therapy.

中文翻译：

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可注射的自组装的bola-deptide水凝胶​​可用于持续的光动力前药输送和增强的肿瘤治疗。

超分子肽材料由于其天然的生物来源和用途广泛而引起了越来越多的关注。然而，控制和调节肽（特别是短肽）的自组装对于构建具有可调节的机械性质和对生物医学应用的适应性可注射性的水凝胶通常是挑战性的。在这里，我们报告了基于合理设计的bola-depteptide的自组装形成坚固且可注射的水凝胶的超分子策略。自组装水凝胶具有多种功能，包括剪切应力下的流动性，良好的恢复性能以及亲水性前药的易囊封性。载有前药的水凝胶显示出持续释放的特性，抑制了非靶向性泄漏并增强了局部前药转化，导致高效的光动力肿瘤消融。因此，超分子策略有望用于合理构建可注射的水凝胶，以实现靶向和持续的前药转化和肿瘤治疗。