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The Role of Circular RNAs in Brain Injury.
Neuroscience ( IF 3.3 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.neuroscience.2019.12.018
Huaxin Zhu 1 , Zelong Xing 2 , Yeyu Zhao 2 , Zheng Hao 2 , Meihua Li 2
Affiliation  

Circular RNAs are an increasingly important topic in non-coding RNA biology, drawing considerable attention in recent years. Accumulating evidence suggests a critical role for circular RNAs in both early and latent stages of disease pathogenesis. Circular RNAs are abundantly expressed in brain tissue, with significant implications for neural development and disease progression. Disruption of these processes, including those seen in response to brain injury, can have serious consequences such as hemiplegia, aphasia, coma, and death. In this review, we describe the role of circular RNAs in the context of brain injury and explore the potential connection between circular RNAs, brain hypoxic ischemic injury, ischemia-reperfusion injury, and traumatic injury.

中文翻译:

环状RNA在脑损伤中的作用。

环状RNA在非编码RNA生物学中正变得越来越重要,近年来引起了极大的关注。越来越多的证据表明,环状RNA在疾病发病机理的早期和潜在阶段都起着至关重要的作用。环状RNA在脑组织中大量表达,对神经发育和疾病进展具有重要意义。这些过程的中断,包括对脑损伤的反应,可能会导致严重的后果,例如偏瘫,失语,昏迷和死亡。在这篇综述中,我们描述了环状RNA在脑损伤背景下的作用,并探讨了环状RNA,脑缺氧缺血性损伤,局部缺血再灌注损伤和创伤性损伤之间的潜在联系。
更新日期:2020-01-07
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