Reduced amplitude and increased latency of P300 auditory event-related potential (ERP) in patients with schizophrenia (SZ) indicate impairment in attention. Overall arousal level can determine the amount of processing capacity required for attention allocation. Music evokes strong emotions and regulates arousability. Music has been used to modulate P300, especially in normals. This exploratory study examined the effect of music listening on the amplitude and latency of P300 in SZ patients. EEG/ERP was recorded (32-channels) while SZ patients (n = 20; 18-45 years) performed an auditory oddball P300 task after the eyes-closed rest condition (Condition-A) and ten-minute music listening condition (Condition-B) as per the complete counterbalancing design (AB-BA). Patients listened to the researcher chosen, instrumental presentation of raag-Bhoopali in the North-Indian-Classical-Music, for ten-minutes. All patients rated the music excerpt as a relaxing and positively valenced. A significant increase in accuracy score and reaction time during the oddball task after music listening was noted. There was an increase in amplitude at TP7. A trend of increased amplitude was noted across all electrodes in the music condition compared to the rest condition. Mean amplitude in an apriori defined time window of interest (250 to 750 ms) showed significant changes in the frontal and central electrode sites. Power spectral analysis indicated a slight increase in frontal and central alpha and theta activity during music listening. However, this was not statistically significant. Findings add further impetus to examine the effect of music in chronic psychiatric conditions. Need for systematic studies on a larger cohort is underscored.

中文翻译：

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听音乐对精神分裂症患者 P300 事件相关电位的影响：一项初步研究

精神分裂症 (SZ) 患者 P300 听觉事件相关电位 (ERP) 的振幅降低和潜伏期增加表明注意力受损。总体唤醒水平可以决定注意力分配所需的处理能力量。音乐唤起强烈的情绪并调节兴奋度。音乐已被用于调制 P300，尤其是在法线中。这项探索性研究检查了听音乐对 SZ 患者 P300 幅度和潜伏期的影响。记录 EEG/ERP（32 通道），而 SZ 患者（n = 20；18-45 岁）在闭眼休息条件（条件 A）和十分钟音乐聆听条件（条件）后执行听觉古怪的 P300 任务-B) 根据完整的平衡设计 (AB-BA)。患者听取了研究人员选择的意见，在北印度古典音乐中演奏 raag-Bhoopali，时长 10 分钟。所有患者都将音乐片段评为轻松且具有积极意义的音乐。注意到在听音乐后的古怪任务期间准确度得分和反应时间显着增加。TP7 的振幅有所增加。与休息条件相比，在音乐条件下的所有电极上都注意到振幅增加的趋势。先验定义的感兴趣时间窗口（250 至 750 ms）中的平均幅度显示正面和中央电极部位发生显着变化。功率谱分析表明，在听音乐期间，额叶和中央 alpha 和 theta 活动略有增加。然而，这在统计学上并不显着。研究结果进一步推动了研究音乐对慢性精神疾病的影响。强调需要对更大的队列进行系统研究。