Uterine has a pivotal role in implantation and conceptus development. To prepare a conducive uterine condition for possibly new gestation during the estrous cycle, uterine endometrium undergoes dramatic remodeling. In addition, angiogenesis is an indispensable biological process of endometrium remodeling. Furthermore, essential protein expressions related to important biological processes of endometrium remodeling, which are vascular endothelial growth factor (VEGF), myoglobin (MYG), collagen type IV (COL4), fucosyltransferase IV (FUT4), and cysteine-rich protein 2 (CRP2), were detected in the endometrial tissue reported in many previous studies and recently discovered in histotroph substrates during the estrous cycle. Those proteins, which are liable for provoking new vessel development, cell proliferation, cell adhesion, and cell migration, were expressed higher in the histotroph during the luteal phase than follicular phase. Histotroph proteins considerably contribute to endometrium remodeling during the estrous cycle. To that end, the following review will discuss and highlight the relevant information and evidence of the uterine fluid proteins as endometrial-secreted factors that adequately indicate the potential role of the uterine secretions to be involved in the endometrial remodeling process.

中文翻译：

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子宫内膜分泌因子在动情周期中对子宫内膜重塑的潜在作用。

子宫在着床和孕体发育中起着关键作用。为了在动情周期期间为可能的新妊娠准备有利的子宫条件，子宫内膜经历了显着的重塑。此外，血管生成是子宫内膜重塑不可或缺的生物学过程。此外，与子宫内膜重塑的重要生物学过程相关的必需蛋白表达，包括血管内皮生长因子 (VEGF)、肌红蛋白 (MYG)、IV 型胶原蛋白 (COL4)、岩藻糖基转移酶 IV (FUT4) 和富含半胱氨酸的蛋白 2 (CRP2) ), 在许多先前研究报告的子宫内膜组织中检测到，最近在发情周期期间在组织营养底物中发现。那些负责激发新血管发育、细胞增殖、细胞粘附和细胞迁移的蛋白质，在黄体期组织营养细胞中的表达高于卵泡期。组织营养蛋白在动情周期期间对子宫内膜重塑有很大贡献。为此，以下综述将讨论并强调子宫液蛋白作为子宫内膜分泌因子的相关信息和证据，这些因子充分表明子宫分泌物在子宫内膜重塑过程中的潜在作用。