By assessing nonhospitalized asymptomatic patients, community-based studies inform the prevalence, key clinical characteristics, and outcomes associated with diastolic dysfunction. As the number of parameters to define and grade diastolic function continues to increase, there has been a shift to a focus on readily obtainable measurements with minimal interobserver variability. In this regard, mitral inflow and annular tissue Doppler velocities, as well as measurement of left atrial volume index, are the most feasible and reproducible. Within communities, variations in definitions have limited generalizability regarding the prevalence and risks associated with diastolic dysfunction. Nevertheless, community-based studies have established important associations with hypertension, obesity, and diabetes. Randomized controlled trials of treatment in heart failure with preserved ejection fraction have been disappointing. Importantly, diastolic dysfunction is consistently associated with higher mortality, which emphasizes the importance of early recognition and initiation of appropriate preventative treatments.

中文翻译：

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基于社区的流行病学研究和HFpEF随机对照试验中舒张功能障碍的影像学。

通过评估未住院的无症状患者，基于社区的研究可告知患病率，关键临床特征以及与舒张功能障碍相关的结局。随着定义和舒张功能分级的参数数量不断增加，人们开始将注意力转移到易于获得的，观察者间差异最小的测量上。在这方面，二尖瓣流入和环形组织多普勒速度以及左心房容积指数的测量是最可行和可重现的。在社区内，定义的变化在与舒张功能障碍相关的患病率和风险方面具有局限性。尽管如此，基于社区的研究已经建立了与高血压，肥胖和糖尿病的重要关联。保留射血分数的心力衰竭治疗的随机对照试验令人失望。重要的是，舒张功能障碍始终伴随着较高的死亡率，这强调了及早认识和开始采取适当预防措施的重要性。