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Microbial production of bioactive chemicals for human health
Current Opinion in Food Science ( IF 9.9 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.cofs.2019.12.007
Xia Wu , Jian Zha , Mattheos AG Koffas

Bioactive compounds are a collection of compounds that have certain effects on humans and animals that consume them. Since many bioactive compounds are beneficial to human health, they are attracting increasing attention in modern life, and their rising consumption stimulates the development of novel production modes that are more efficient than the traditional way, which relies on chemical synthesis or extraction from natural tissues. Among the emerging production techniques, biotechnology-based generation using fermentation of genetically engineered microorganisms shows great potential as an alternative to the current manufacturing systems, and has actually been applied for the industrial supply of some bioactive compounds. In this review, we highlight the microbial production of some typical bioactive compounds, including polyphenols, polysaccharides, amino acids, and vitamins. Also, we discuss the underlying disadvantages of some microbial systems and point out the future directions for system optimization.



中文翻译:

微生物生产生物活性化学品对人类健康的影响

生物活性化合物是对食用它们的人和动物有某些影响的化合物的集合。由于许多生物活性化合物有益于人体健康,因此它们在现代生活中正受到越来越多的关注,并且其不断增长的消费量刺激了新型生产方式的发展,这种生产方式比传统方式更有效,传统方式依靠化学合成或从天然组织中提取。在新兴的生产技术中,使用基因工程微生物发酵的基于生物技术的发电显示出巨大的潜力,可以替代当前的生产系统,并且已被实际用于某些生物活性化合物的工业供应。在这篇评论中,我们重点介绍了一些典型的生物活性化合物(包括多酚,多糖,氨基酸和维生素。另外,我们讨论了某些微生物系统的潜在弊端,并指出了系统优化的未来方向。

更新日期:2020-01-07
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