The present study designed to investigate the protective effect of curcumin nanoparticles (CUR-NPs) on the cardiotoxicity induced by doxorubicin. Rats were divided into four groups; control, rats treated daily with CUR-NPs (50 mg/kg) for 14 days, rats treated with an acute dose of doxorubicin (20 mg/kg) and rats treated daily with CUR-NPs for 14 days injected with doxorubicin on the 10th day. After electrocardiogram (ECG) recording from rats at different groups, rat decapitation was carried out and the heart of each rat was excised out to measure the oxidative stress parameters; lipid peroxidation (MDA), nitric oxide (NO) and reduced glutathione (GSH) and the activities of Na,K,ATPase and acetylcholinesterase (AchE). In addition, the levels of dopamine (DA), norepinephrine (NE) and serotonin (5-HT) were determined in the cardiac tissues. Lactate dehydrogenase (LDH) activity was measured in the serum. The ECG recordings indicated that daily pretreatment with CUR- NPs has prevented the tachycardia (i.e. increase in heart rate) and ameliorated the changes in ST wave and QRS complex induced by doxorubicin. In addition, CUR-NPs prevented doxorubicin induced significant increase in MDA, NO, DA, AchE and LDH and doxorubicin induced significant decrease in GSH, NE, 5-HT and Na,K,ATPase. According to the present findings, it could be concluded that CUR-NPs have a protective effect against cardiotoxicity induced by doxorubicin. This may shed more light on the importance of CUR-NPs pretreatment before the application of doxorubicin therapy.

中文翻译：

---

姜黄素纳米颗粒对阿霉素诱导的大鼠心脏毒性的保护作用。

本研究旨在研究姜黄素纳米颗粒（CUR-NPs）对阿霉素诱导的心脏毒性的保护作用。大鼠分为四组。对照，在第10天每天用CUR-NPs（50 mg / kg）治疗14天的大鼠，在急性剂量下用阿霉素（20 mg / kg）治疗的大鼠和每天用CUR-NPs治疗14天的大鼠注射阿霉素天。记录不同组大鼠的心电图（ECG）后，将其断头并切除每只大鼠的心脏，以测定其氧化应激参数。脂质过氧化（MDA），一氧化氮（NO）和还原型谷胱甘肽（GSH）以及Na，K，ATPase和乙酰胆碱酯酶（AchE）的活性。此外，测定了心脏组织中的多巴胺（DA），去甲肾上腺素（NE）和血清素（5-HT）的水平。测定血清中的乳酸脱氢酶（LDH）活性。心电图记录表明，每天用CUR-NP预处理可预防心动过速（即心率增加）并减轻阿霉素引起的ST波和QRS复合物的变化。此外，CUR-NPs阻止了阿霉素诱导的MDA，NO，DA，AchE和LDH的显着增加，而阿霉素诱导的GSH，NE，5-HT和Na，K，ATPase的显着减少。根据目前的发现，可以得出结论，CUR-NP对由阿霉素引起的心脏毒性具有保护作用。这可能会更清楚地说明在应用阿霉素治疗之前进行CUR-NPs预处理的重要性。e。心率增加）并改善了阿霉素引起的ST波和QRS复合物的变化。此外，CUR-NPs阻止了阿霉素诱导的MDA，NO，DA，AchE和LDH的显着增加，而阿霉素诱导的GSH，NE，5-HT和Na，K，ATPase的显着减少。根据目前的发现，可以得出结论，CUR-NP对由阿霉素引起的心脏毒性具有保护作用。这可能会更清楚地说明在应用阿霉素治疗之前进行CUR-NPs预处理的重要性。e。心率增加）并改善了阿霉素引起的ST波和QRS复合物的变化。此外，CUR-NPs阻止了阿霉素诱导的MDA，NO，DA，AchE和LDH的显着增加，而阿霉素诱导的GSH，NE，5-HT和Na，K，ATPase的显着减少。根据目前的发现，可以得出结论，CUR-NP对由阿霉素引起的心脏毒性具有保护作用。这可能会更清楚地说明在应用阿霉素治疗之前进行CUR-NPs预处理的重要性。根据目前的发现，可以得出结论，CUR-NP对由阿霉素引起的心脏毒性具有保护作用。这可能会更清楚地说明在应用阿霉素治疗之前进行CUR-NPs预处理的重要性。根据目前的发现，可以得出结论，CUR-NP对由阿霉素引起的心脏毒性具有保护作用。这可能会更清楚地说明在应用阿霉素治疗之前CUR-NPs预处理的重要性。