K11/K48-branched ubiquitin chains are proteasomal priority signals that elicit the rapid elimination of mitotic regulators and aggregation-prone proteins. Indicative of an intriguing signaling mode, Boughton et al. (2019) unravel an interaction between distal subunits of K11/K48-branched ubiquitin trimers that could provide a combined surface for recognition by the proteasomal receptor RPN1.

中文翻译：

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接近：洞悉K11 / K48支链泛素链的结构和功能。

K11 / K48分支的泛素链是蛋白酶体优先信号，可引起有丝分裂调节剂和易聚集蛋白的快速消除。Boughton等人指出了一种有趣的信号传导模式。（2019）揭示了K11 / K48分支的泛素三聚体的远侧亚基之间的相互作用，该相互作用可以提供蛋白酶体受体RPN1识别的组合表面。