In this issue of Cell Metabolism, El Ouarrat et al. identify the Hippo signaling terminal effector TAZ as an endogenous negative regulator of PPARγ, a master transcriptional regulator of lipid metabolism and insulin sensitivity. Selective destruction of TAZ in adipocytes lowers inflammation and restores insulin sensitivity and glucose homeostasis.

中文翻译：

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TAZ的丧失会增强PPARγ以应对胰岛素抵抗。

在《细胞代谢》杂志中，El Ouarrat等人。确定Hippo信号传递末端效应子TAZ为PPARγ的内源性负调节剂，是脂质代谢和胰岛素敏感性的主要转录调节剂。选择性破坏脂肪细胞中的TAZ可降低炎症并恢复胰岛素敏感性和葡萄糖稳态。