Neurodegenerative diseases are linked to dysfunctional proteostasis and disturbed autophagy. Here, we discuss how the sigma-1 receptor (Sig-1R) may act at the intersection of this interaction, as loss-of-function mutations of this unique chaperone are associated with defective autophagy and its pharmacological activation induces autophagic activity.

中文翻译：

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位于蛋白质稳态、神经变性和自噬十字路口的 Sigma-1 受体

神经退行性疾病与功能失调的蛋白质稳态和自噬障碍有关。在这里，我们讨论了 sigma-1 受体 (Sig-1R) 如何在这种相互作用的交叉点起作用，因为这种独特伴侣蛋白的功能丧失突变与自噬缺陷相关，并且其药理学激活诱导自噬活性。