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Metabolic Engineering of Escherichia coli for Natural Product Biosynthesis.
Trends in Biotechnology ( IF 17.3 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.tibtech.2019.11.007
Dongsoo Yang 1 , Seon Young Park 1 , Yae Seul Park 1 , Hyunmin Eun 1 , Sang Yup Lee 2
Affiliation  

Natural products are widely employed in our daily lives as food additives, pharmaceuticals, nutraceuticals, and cosmetic ingredients, among others. However, their supply has often been limited because of low-yield extraction from natural resources such as plants. To overcome this problem, metabolically engineered Escherichia coli has emerged as a cell factory for natural product biosynthesis because of many advantages including the availability of well-established tools and strategies for metabolic engineering and high cell density culture, in addition to its high growth rate. We review state-of-the-art metabolic engineering strategies for enhanced production of natural products in E. coli, together with representative examples. Future challenges and prospects of natural product biosynthesis by engineered E. coli are also discussed.



中文翻译:

天然产物生物合成的大肠杆菌代谢工程。

天然产品广泛应用于我们的日常生活中,包括食品添加剂,药品,保健食品和化妆品成分等。然而,由于从诸如植物的自然资源中提取的产量低,它们的供应常常受到限制。为了克服这个问题,代谢工程化的大肠杆菌已经成为天然产物生物合成的细胞工厂,这是因为它具有许多优势,包括其成熟度高,可用于代谢工程和高细胞密度培养的成熟工具和策略。我们回顾了最新的代谢工程策略,以增强大肠杆菌中天然产物的产量以及代表性示例。还讨论了通过工程化大肠杆菌进行天然产物生物合成的未来挑战和前景。

更新日期:2020-01-07
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