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Serum cytokines associated with behavior: a cross-sectional study in 5-year-old children
Brain, Behavior, and Immunity ( IF 15.1 ) Pub Date : 2020-07-01 , DOI: 10.1016/j.bbi.2020.01.005
Susana Barbosa 1 , Olfa Khalfallah 1 , Anne Forhan 2 , Cédric Galera 3 , Barbara Heude 2 , Nicolas Glaichenhaus 1 , Laetitia Davidovic 1
Affiliation  

Nearly 10% of 5-year-old children experience social, emotional or behavioral problems and are at increased risk of developing mental disorders later in life. While animal and human studies have demonstrated that cytokines can regulate brain functions, it is unclear whether individual cytokines are associated with specific behavioral dimensions in population-based pediatric samples. Here, we used data and biological samples from 786 mother-child pairs participating to the French national mother-child cohort EDEN. At the age of 5, children were assessed for behavioral difficulties using the Strengths and Difficulties Questionnaire (SDQ) and had their serum collected. Serum samples were analyzed for levels of well-characterized effector or regulatory cytokines. We then used the Elastic net model, a penalized logistic regression method, to investigate associations between serum levels of cytokines and each of the five SDQ-assessed behavioral dimensions after adjustment for relevant covariates and confounders, including psychosocial variables. We found that interleukin (IL)-6, IL-7, and IL-15 were associated with increased odds of problems in prosocial behavior, emotions, and peer relationships, respectively. In contrast, eight cytokines were associated with decreased odds of problems in one dimension: IL-8, IL-10, and IL-17A with emotional problems, Tumor Necrosis Factor (TNF)-α with conduct problems, C-C motif chemokine Ligand (CCL)2 with hyperactivity/inattention, C-X-C motif chemokine Ligand (CXCL)10 with peer problems, and CCL3 and IL-16 with abnormal prosocial behavior. Without implying causation, these associations support the notion that cytokines regulate brain functions and behavior and provide a rationale for launching longitudinal studies.

中文翻译:

与行为相关的血清细胞因子:5 岁儿童的横断面研究

近 10% 的 5 岁儿童经历过社交、情感或行为问题,并且在以后的生活中患精神障碍的风险增加。虽然动物和人类研究表明细胞因子可以调节大脑功能,但尚不清楚单个细胞因子是否与基于人群的儿科样本中的特定行为维度相关。在这里,我们使用了参加法国国家母子队列 EDEN 的 786 对母子的数据和生物样本。在 5 岁时,使用优势和困难问卷 (SDQ) 评估儿童的行为困难并收集他们的血清。分析了血清样品中充分表征的效应因子或调节细胞因子的水平。然后我们使用弹性网络模型,一种惩罚逻辑回归方法,在调整相关协变量和混杂因素(包括社会心理变量)后,研究血清细胞因子水平与 SDQ 评估的五个行为维度中的每一个之间的关联。我们发现白细胞介素 (IL)-6、IL-7 和 IL-15 分别与亲社会行为、情绪和同伴关系中出现问题的几率增加有关。相比之下,八种细胞因子与一维问题的几率降低相关:IL-8、IL-10 和 IL-17A 与情绪问题、肿瘤坏死因子 (TNF)-α 与行为问题、CC 基序趋化因子配体 (CCL )2 多动/注意力不集中,CXC 基序趋化因子配体 (CXCL)10 有同伴问题,CCL3 和 IL-16 有异常亲社会行为。在不暗示因果关系的情况下,
更新日期:2020-07-01
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