Amyotrophic Lateral Sclerosis (ALS) leads to functional capacity decline, generating great impact in quality of life. Quality of life is directly related to physical integrity and functional independence. This systematic review aimed to analyze treatment protocols and their outcomes from clinical trials with focus on ALS rehabilitation that evaluated the effects on quality of life and functional independence from their intervention process. A literature search was conducted through MEDLINE-PubMed, Science Direct, Web of Science and Scopus databases. A total of 3630 articles were identified. Eleven studies met the inclusion criteria. They focused on different aspects of quality of life or functional independence, which are: respiratory care, mental health, communication skills and exercises. Use of bipap and inspiratory muscle training, anxiety and depression, communication devices implementation and exercises safety and tolerability were considered as key points. However, the drastic evolution of the disease is a limiting factor to the perception of quality of life improvement by patients. Further studies should be done to validate the benefits on patients' quality of life.

中文翻译：

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肌萎缩性侧索硬化症的生活质量和功能独立性：系统评价。

肌萎缩性侧索硬化症（ALS）导致功能能力下降，对生活质量产生重大影响。生活质量与身体完整性和功能独立性直接相关。该系统评价旨在分析治疗方案及其从临床试验中得到的结果，重点是ALS康复，该研究评估了干预过程对生活质量和功能独立性的影响。通过MEDLINE-PubMed，Science Direct，Web of Science和Scopus数据库进行了文献检索。总共确定了3630条文章。十一项研究符合纳入标准。他们关注生活质量或功能独立性的不同方面，包括：呼吸保健，心理健康，沟通技巧和锻炼。使用双足点和吸气肌肉训练，焦虑和抑郁，通讯设备的使用以及锻炼的安全性和耐受性被认为是重点。但是，疾病的急剧发展是限制患者对患者生活质量改善的认识的限制因素。应该做进一步的研究以验证对患者生活质量的益处。