Dynamic regulation of lysosomes allows them to play key roles in cell and tissue homeostasis. In this issue of Developmental Cell, Miao et al. find that a novel transcriptional pathway triggered by loss of cell adhesion activates lysosomes in C. elegans epidermis during developmental remodeling of the cuticle.

中文翻译：

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分子水平调节：溶酶体参与秀丽隐杆线虫的发育ECM重塑。

溶酶体的动态调节使它们在细胞和组织体内平衡中起关键作用。在本期《发育细胞》中，Miao等人。发现由细胞粘附丧失触发的新型转录途径在表皮的发育重塑过程中激活秀丽隐杆线虫表皮中的溶酶体。