Abstract

In this paper, a rapid, easy and very efficient method for the synthesis of bis(pyrazolyl)methanes has been reported in the presence of nickel–guanidine complex immobilized on MCM-41 (MCM-41@Gu@Ni) as a recyclable nanocatalyst. This mesoporous silica catalyst was effective for the one-pot multi-component reaction of arylaldehydes, phenylhydrazine and ethyl acetoacetate in ethanol solvent. The current synthesis shows attractive features, for example the use of recoverable and reusable nanocatalyst (5 times), easy workup, suitable one-pot procedure, short reaction times, good to excellent yields and moderate reaction conditions.

Graphic abstract

中文翻译：

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使用固定在MCM-41上的镍-胍配合物合成双（吡唑基）甲烷的简单，快速，有效方案

摘要

在本文中，已经报道了在固定化为可回收纳米催化剂的MCM-41（MCM-41 @ Gu @ Ni）上存在镍-胍络合物的情况下，一种快速，简便且非常有效的合成双（吡唑基）甲烷的方法。 。该介孔二氧化硅催化剂对于在乙醇溶剂中芳基醛，苯肼和乙酰乙酸乙酯的一锅多组分反应有效。当前的合成方法显示出吸引人的特征，例如使用可回收和可重复使用的纳米催化剂（5次），易于后处理，适用于一锅法操作，反应时间短，产率高且反应条件中等。

图形摘要