BACKGROUND Mechanical stimulation of the stretch receptors of the gastric wall can simulate the presence of indigested food leading to reduced food intake. We report the preliminary experimental results of an innovative concept of localized mechanical gastric stimulation. METHODS In a first survival study, a biocompatible bulking agent was injected either in the greater curvature (n = 8) or in the cardia wall (n = 8) of Wistar rats. Six animals served as sham. Changes of bulking volume, leptin levels and weight gain were monitored for 3 months. In a second acute study, a micro-motor (n = 10; MM) or a size-paired inactive device (n = 10; ID) where applied on the cardia, while 10 additional rats served as sham. Serum ghrelin and leptin were measured at baseline and every hour (T0-T1-T2-T3), during 3 h. In a third study, 24 implants of various shapes and sizes were introduced into the gastric subserosa of 6 Yucatan pigs. Monthly CT scans and gastroscopies were done for 6 months. RESULTS Weight gain in the CW group was significant lower after 2 weeks and 3 months when compared to the shame and GC (p = 0.01/p = 0.01 and p = 0.048/p = 0.038 respectively). Significant lower increase of leptin production occurred at 2 weeks (p = 0.01) and 3 months (p = 0.008) in CW vs. SG. In the MM group significant reduction of the serum ghrelin was seen after 3 h. Leptin was significantly increased in both MM and ID groups after 3 h, while it was significantly reduced in sham rats. The global device retention was 43.5%. Devices with lower profile and with a biocompatible coating remained more likely in place without complications. CONCLUSIONS Gastric mechanical stimulation induced a reduced weight gain and hormonal changes. Low profile and coated devices inserted within the gastric wall are more likely to be integrated.

中文翻译：

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GAMMA概念（通过调节肠胃活动来调节食欲）是局部振动胃机械刺激概念的初步证明。

背景技术对胃壁的拉伸受体的机械刺激可以模拟消化不良食物的存在，从而导致食物摄入减少。我们报告了局部机械性胃刺激的创新概念的初步实验结果。方法在一项首次生存研究中，向Wistar大鼠的较大曲率（n = 8）或in门壁（n = 8）注射生物相容性填充剂。六只动物作假。连续3个月监测体积，瘦素水平和体重增加的变化。在第二项急性研究中，将card微电机（n = 10; MM）或大小配对的不活动设备（n = 10; ID）应用于the门肌，另外10只大鼠作为假手术。在基线和每小时（T0-T1-T2-T3）的3小时内测量血清生长激素释放肽和瘦素。在第三项研究中 将24种不同形状和大小的植入物引入6头尤卡坦猪的胃下浆膜中。每月进行CT扫描和胃镜检查6个月。结果与羞耻和GC相比，CW组的体重增加在2周和3个月后显着降低（分别为p = 0.01 / p = 0.01和p = 0.048 / p = 0.038）。与SG相比，在2周（p = 0.01）和3个月（p = 0.008）时，瘦素产量显着降低。在MM组中，3小时后血清ghrelin明显降低。瘦素在MM和ID组均在3 h后显着增加，而在假大鼠中则显着降低。全球设备保留率为43.5％。具有较低轮廓和具有生物相容性涂层的设备更可能留在原地，而不会出现并发症。结论胃机械刺激可减轻体重增加和荷尔蒙变化。插入胃壁内的薄型和涂层设备更可能集成在一起。