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Clinical Significance and Outcomes in Trial of Nabiximols for Treatment of Cannabis Dependence-Reply.
JAMA Internal Medicine ( IF 39.0 ) Pub Date : 2020-01-01 , DOI: 10.1001/jamainternmed.2019.5670
Nicholas Lintzeris 1, 2 , Jan Copeland 3 , Raimondo Bruno 4
Affiliation  

In Reply Kleinman and Ostacher assert that in our article,1 we “have switched primary outcomes between study registration and publication, thereby inaccurately portraying the trial results.” The study registration listed the primary end point as 4-week point prevalence abstinence by combining self-reported data from researcher interviews with the objective measures of unsanctioned cannabis use. Unsanctioned cannabis use was also reported as mean days used and percentage of positive results on urine drug screening tests.



中文翻译:

纳比昔莫尔治疗大麻依赖性应答的临床意义和结果。

Kleinman和Ostacher的回复中断言,在我们的文章中1,“我们已经在研究注册和发表之间切换了主要结果,从而不准确地描述了试验结果。” 研究注册通过将研究人员访谈中的自我报告数据与未经批准的大麻使用的客观指标相结合,将主要终点列为4周戒除流行病。还报告了未经批准使用大麻的情况,即使用的平均天数和尿液药物筛选试验阳性结果的百分比。

更新日期:2020-01-06
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