The field of single-cell RNA sequencing (scRNA-seq) has been paired with genomics, epigenomics, spatial omics, proteomics and imaging to achieve multimodal measurements of individual cellular phenotypes and genotypes. In its purest form, single-cell multimodal omics involves the simultaneous detection of multiple traits in the same cell. More broadly, multimodal omics also encompasses comparative pairing and computational integration of measurements made across multiple distinct cells to reconstruct phenotypes. Here I highlight some of the biological insights gained from multimodal studies and discuss the challenges and opportunities in this emerging field.

中文翻译：

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单细胞生物学：超出其各个部分的总和。

单细胞RNA测序（scRNA-seq）领域已与基因组学，表观基因组学，空间组学，蛋白质组学和成像技术相结合，以实现对单个细胞表型和基因型的多峰测量。在最纯净的形式中，单细胞多峰组学涉及同时检测同一细胞中的多个性状。更广泛地说，多峰组学还包括比较配对和跨多个不同细胞进行的测量结果的计算整合，以重建表型。在这里，我重点介绍了从多模式研究中获得的一些生物学见解，并讨论了这一新兴领域中的挑战和机遇。