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Phagocytosis: Mechanosensing, Traction Forces, and a Molecular Clutch.
Current Biology ( IF 9.2 ) Pub Date : 2020-01-06 , DOI: 10.1016/j.cub.2019.11.047
Spencer A Freeman 1 , Sergio Grinstein 2
Affiliation  

The forces driving membrane protrusion during phagocytosis are poorly understood. A recent study describes how integrins in the phagocyte membrane provide a molecular clutch to enable the exertion of force by actin polymerizing at the leading edge of the pseudopods. These results explain the mechanosensitivity of phagocytic cells.

中文翻译:

吞噬作用:机械传感,牵引力和分子离合器。

在吞噬过程中驱动膜突出的力了解甚少。最近的研究描述了吞噬细胞膜中的整联蛋白如何提供分子离合器以通过肌动蛋白在假足的前缘聚合来施加力。这些结果解释了吞噬细胞的机械敏感性。
更新日期:2020-01-06
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