The immune system is increasingly recognized to play an integral role in regulating stress responses. In a recent article in Cell, Fan et al. demonstrate a novel mechanism through which stress drives mitochondrial fragmentation-induced xanthine accumulation in mouse CD4+ T cells, subsequently acting on oligodendrocytes to induce anxiety-like behaviors.

中文翻译：

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压力过大的T细胞会使心灵破碎。

人们越来越认识到免疫系统在调节压力反应中起着不可或缺的作用。Fan等人在Cell的最新文章中。证明了一种新的机制，应力可通过该机制驱动小鼠CD4 + T细胞中的线粒体片段化诱导的黄嘌呤积累，随后作用于少突胶质细胞以诱导焦虑样行为。