BACKGROUND In 2009, both Norway and Denmark initiated routine quadrivalent human papillomavirus vaccination (qHPV) for 12-year-old girls; however, Denmark also introduced free-of-charge multi-cohort vaccination for older age groups in 2008. We aim to describe trends in genital warts (GWs) incidence rates (IRs) among men and women and qHPV vaccine coverage among women in Norway and Denmark in 2006-2015. METHODS We linked multiple national health registries in Norway and Denmark via national personal identifiers to access data on GWs incidence and qHPV vaccination among women and men aged 12-35 years residing in Norway and Denmark in 2006-2015. We calculated age-specific and age-standardized GWs IRs, GWs IR trends before (2006-2009) and after (2009-2015) the implementation of qHPV vaccination, and qHPV vaccine coverage among women. RESULTS In Norway and Denmark together, there were more than 200,000 cases of incident GWs and over 710,000 girls got at least one dose of qHPV vaccine during the study period. The total qHPV coverage in Norway and Denmark in 2015 was among women aged 12-35 years 24% and 70%, respectively. GWs IRs in Norway and Denmark decreased annually in 2009-2015 among women by 4.8% (95% confidence interval: 4.3 to 5.3) and 18.0% (95%CI: 17.5 to 18.6), respectively, and among men 1.9% (95%CI: 1.4 to 2.4) and 10.7% (95%CI: 10.3 to 11.2), respectively. In Denmark, GWs IRs decreased rapidly among both sexes and all age groups after qHPV vaccination, while Norway showed only a modest decrease. CONCLUSION Rapid decline in HPV-related morbidity is feasible with high coverage of multi-cohort vaccination. However, the decision to vaccinate a single cohort of 12-years-old girls only will postpone HPV-related disease control by at least a decade. Thus countries planning HPV vaccination programs should also initiate multi-cohort vaccination for faster disease control.

中文翻译：

---

HPV多队列疫苗接种的影响：更快控制HPV相关发病率的现实证据。

背景技术2009年，挪威和丹麦都针对12岁女孩开始了常规的四价人乳头瘤病毒疫苗（qHPV）接种；但是，丹麦在2008年还针对老年人群免费提供了多队列疫苗接种。我们旨在描述男性和女性生殖器疣（GWs）发病率（IRs）的趋势以及挪威和挪威女性的qHPV疫苗覆盖率丹麦2006-2015年。方法我们通过国家个人标识符将挪威和丹麦的多个国家卫生注册机构链接在一起，以访问2006-2015年居住在挪威和丹麦的12-35岁男女的GWs发病率和qHPV疫苗接种数据。我们计算了特定年龄和标准化年龄的GWs IR，在实施qHPV疫苗接种之前（2006-2009年）和之后（2009-2015年）GWs IR趋势以及妇女中的qHPV疫苗覆盖率。结果在研究期间，挪威和丹麦总共有超过200,000例GW病例，超过710,000名女孩至少接种了一剂qHPV疫苗。2015年，挪威和丹麦的qHPV总覆盖率分别为12-35岁的女性，24％和70％。在2009-2015年间，挪威和丹麦的GWs IRs每年分别下降4.8％（95％置信区间：4.3至5.3）和18.0％（95％CI：17.5至18.6），男性下降1.9％（95％） CI：1.4到2.4）和10.7％（95％CI：10.3到11.2）。在丹麦，qHPV疫苗接种后，性别和所有年龄段的GWs IR均迅速下降，而挪威仅适度下降。结论HPV相关发病率的快速下降在多人群疫苗接种的高覆盖率下是可行的。然而，仅对一个12岁女孩进行疫苗接种的决定将把与HPV相关的疾病控制推迟至少十年。因此，计划进行HPV疫苗接种计划的国家还应该启动多队列疫苗接种，以更快地控制疾病。