Wogonin (5,7-dihydroxy-8-methoxy flavone), an active component isolated from the root of Scutellaria baicalensis Georgi. Neurotoxic effects of γ irradiation have been established in humans and animals. The current study was designed to evaluate whether wogonin could restrain γ irradiation-induced neurotoxicity in rats and to explore the underlying mechanisms. Rats were divided into five groups, 10 rats each. Group 1 was orally administered distilled water and served as control. Group 2 received an oral daily dose of wogonin (30 mg/kg). Rats in group 3 were exposed to a whole-body single dose of γ-irradiation. Animals in group 4 received an oral daily dose of wogonin (30 mg/kg) for 15 days then exposed to a whole-body single dose of γ-irradiation. In group 5, rats were exposed to a whole-body single dose of γ-irradiation then were orally administered a daily dose of wogonin (30 mg/kg) for 15 days. There were significant increases in malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and Interleukin 6 (IL-6) levels and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) mRNA and protein expression. Whereas significant decreases in reduced glutathione (GSH), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) level as well as nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) mRNA and protein expression in the irradiated group when compared with the relevant control. The cerebral cortex of irradiated rats showed vacuolization and nuclear pyknosis in the neuronal cells and focal gliosis. Wogonin administration pre- or post-irradiation significantly ameliorated all these previous effects. Wogonin had antioxidant and anti-inflammatory effects and ameliorated the histopathological changes in the brain.

中文翻译：

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Wogonin对γ射线照射的大鼠大脑的神经保护作用。

Wogonin（5,7-dihydroxy-8-methoxy flavone），一种从黄cut根中分离出的活性成分。γ射线的神经毒性作用已在人类和动物中确立。目前的研究旨在评估沃戈宁是否可以抑制γ射线照射对大鼠的神经毒性，并探讨其潜在机制。将大鼠分为五组，每组十只。第1组口服蒸馏水作为对照组。第2组接受口服口服口服性欲素（30 mg / kg）。第3组的大鼠接受全身单剂量γ射线照射。第4组的动物每天口服口服wogonin（30 mg / kg），持续15天，然后进行全身一次γ射线辐照。在第5组中 将大鼠暴露于全身单一剂量的γ辐射，然后口服给予每日剂量的wogonin（30 mg / kg），持续15天。活化的丙二醛（MDA），肿瘤坏死因子-α（TNF-α），白细胞介素1β（IL-1β）和白细胞介素6（IL-6）的水平显着增加，激活的核因子κ-轻链增强子。 B细胞（NF-κB）mRNA和蛋白质表达。而降低的谷胱甘肽（GSH），超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPX）水平以及核因子红系2相关因子2（Nrf2）和血红素加氧酶-1（HO-1）明显降低）与相关对照组相比，受辐照组的mRNA和蛋白质表达。受辐照大鼠的大脑皮层在神经元细胞和局灶性神经胶质细胞增生中出现空泡化和核固缩。辐照前或辐照后服用沃贡宁可显着改善所有这些先前的影响。Wogonin具有抗氧化和抗炎作用，并改善了大脑的组织病理学变化。