Phytophenols are important bioactive food based chemical entities, largely present in several natural sources. Among them, sesamol is one of the key natural phenols found in sesame seeds, Piper cubeba etc. Several studies have reported that sesame oil is a potent cardioprotective functional food. Papers on the utility of sesamol in sesame oil (the chemical name of sesamol is methylenedioxyphenol, MDP) have appeared in the literature, though there is no single concise review on the usefulness of sesamol in sesame oil in CVD in the literature. Cardiovascular disease (CVD) is the most challenging health problem encountered by the global population. There has been increasing interest in the growth of effective cardiovascular therapeutics, specifically of natural origin. Among various natural sources of chemicals, phytochemicals are micronutrients and bio-compatible scaffolds having an extraordinary efficacy at multiple disease targets with minimal or no adverse effect. This review offers a perspective on the existing literature on functional ingredients in sesame oil with particular focus on sesamol and its derivatives having nutritional and cardioprotective properties. This is demonstrated to have shown a specifically modulating oxidative enzyme myeloperoxidase (MPO) and other proteins which are detrimental to human well-being. The molecular mechanism of cardioprotection by this food ingredient is primarily attributed to the methylenedioxy group present in the sesamol component.

中文翻译：

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芝麻酚：来自芝麻油的强大功能性食品成分，可保护心脏。

植物酚是重要的基于生物活性食品的化学物质，主要存在于几种天然来源中。其中，芝麻酚是芝麻，Piper cubeba等中发现的主要天然酚类之一。几项研究报道说，芝麻油是一种有效的心脏保护功能性食品。关于芝麻油在芝麻油中的用途（芝麻油的化学名称为亚甲基二氧苯酚，MDP）的论文已有报道，尽管文献中没有对芝麻油中芝麻油在CVD中的实用性进行简要的概述。心血管疾病（CVD）是全球人口面临的最具挑战性的健康问题。人们对有效的心血管疗法，特别是天然的心血管疗法的增长越来越感兴趣。在各种天然化学物质中，植物化学物质是微量营养素和生物相容性支架，在多种疾病靶标上具有非凡的功效，且副作用极小或无副作用。这篇综述提供了有关香油中功能性成分的现有文献的观点，尤其侧重于芝麻酚及其具有营养和心脏保护特性的衍生物。已证明这显示出特异性调节氧化酶髓过氧化物酶（MPO）和其他对人体健康有害的蛋白质。该食品成分对心脏的保护作用的分子机理主要归因于芝麻酚成分中存在的亚甲二氧基。这篇综述提供了有关香油中功能性成分的现有文献的观点，尤其侧重于芝麻酚及其具有营养和心脏保护特性的衍生物。已证明这显示出特异性调节氧化酶髓过氧化物酶（MPO）和其他对人体健康有害的蛋白质。该食品成分对心脏的保护作用的分子机理主要归因于芝麻酚成分中存在的亚甲二氧基。这篇综述提供了有关香油中功能性成分的现有文献的观点，尤其侧重于芝麻酚及其具有营养和心脏保护特性的衍生物。已证明这显示出特异性调节氧化酶髓过氧化物酶（MPO）和其他对人体健康有害的蛋白质。该食品成分对心脏的保护作用的分子机理主要归因于芝麻酚成分中存在的亚甲二氧基。