Lactic acid‐fermented garlic extract (LAFGE) has been shown to have hepatoprotective role in liver diseases. This study was conducted to evaluate the efficacy of a new LAFGE‐based hepatoprotective functional food product (named D‐18‐007) formulated with other additive components, including l‐arginine, l‐ornithine, and the leaf extract of licorice and artichoke. In a rat model of d‐galactosamine(GalN)/LPS‐induced liver injury, the survival was significantly higher in animals treated with D‐18‐007 than in animals treated with LAFGE. The hepatic injury was alleviated by either LAFGE or D‐18‐007, but the overall effect was more significant in D‐18‐007, as shown by the necrosis, histology, and serum analyses. Also, the decrease in GalN/LPS‐induced lipid peroxidation in the liver tissue was more significant in D‐18‐007 than LAFGE. The decrease in IL‐6 protein in the liver was similar between LAFGE and D‐18‐007. Moreover, we compared the amount of the bile in normal animals and found that D‐18‐007 has better choleretic activity than LAFGE. Using this acute liver injury model, our results suggest that D‐18‐007 has an enhanced hepatoprotective effect in acute liver injury compared with LAFGE alone.

中文翻译：

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新型乳酸发酵大蒜提取物功能性食品对急性肝损伤的保肝作用

乳酸发酵大蒜提取物（LAFGE）已显示在肝脏疾病中具有保肝作用。这项研究旨在评估一种基于LAFGE的新型肝保护功能性食品（命名为D-18-007）的功效，该产品与其他添加成分（包括l-精氨酸，l-鸟氨酸以及甘草和朝鲜蓟的叶提取物）配制在一起。在d的大鼠模型中由半乳糖胺（GalN）/ LPS诱导的肝损伤，经D-18-007治疗的动物的存活率明显高于经LAFGE治疗的动物。LAFGE或D‐18‐007减轻了肝损伤，但坏死，组织学和血清分析显示，D‐18‐007的总体作用更为显着。同样，在D-18-007中，GalN / LPS诱导的肝组织脂质过氧化的降低比LAFGE更明显。肝中IL-6蛋白的减少在LAFGE和D-18-007之间是相似的。此外，我们比较了正常动物的胆汁量，发现D‐18‐007的胆汁活性比LAFGE好。使用这种急性肝损伤模型，我们的结果表明，与单独的LAFGE相比，D-18-007在急性肝损伤中具有增强的肝保护作用。