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The relationship between HbA1c and hypoglycaemia in patients with diabetes treated with insulin degludec versus insulin glargine 100 units/mL
Diabetes, Obesity & Metabolism ( IF 6.133 ) Pub Date : 2020-01-24 , DOI: 10.1111/dom.13954
Athena Philis‐Tsimikas; Wendy Lane; Ulrik Pedersen‐Bjergaard; Carol Wysham; Lars Bardtrum; Signe Harring; Simon Heller

Treat‐to‐target, randomized controlled trials have confirmed lower rates of hypoglycaemia at equivalent glycaemic control with insulin degludec (degludec) versus insulin glargine 100 units/mL (glargine U100) in patients with type 1 (T1D) or type 2 diabetes (T2D). Treat‐to‐target trials are designed to enable comparisons of safety and tolerability at a similar HbA1c level. In this post hoc analysis of the SWITCH 1 and 2 trials, we utilised a patient‐level modelling approach to compare how glycaemic control might differ between basal insulins at a similar rate of hypoglycaemia.
更新日期:2020-01-26

 

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