OBJECTIVES Studies have demonstrated that children from aggressive periodontitis (AgP) parents presented precocious alterations in their periodontal condition, and the use of chemical agents in association to plaque control could be useful to control these alterations. This study aimed to evaluate the effect of Triclosan toothpaste to modulate the clinical and subgingival condition in children from AgP parents. METHODS Fifteen children from AgP parents and 15 from periodontally healthy parents were included in this crossover placebo study. Children were randomly allocated into triclosan or placebo therapy, using selected toothpaste for 45 days. After 15 days of wash-out, groups were crossed, changing the used toothpaste. Clinical examination and saliva, crevicular gingival fluid (GCF), and subgingival biofilm collection were performed at baseline and 45 days of each phase. GCF cytokines' levels were analyzed by Luminex/MAGpix platform and subgingival and salivary periodontal pathogens' levels by qPCR. RESULTS At baseline, AgP group presented higher plaque index (PI), gingival index (GI), and bleeding on probing (BoP), higher Aggregatibacter actinomycetemcomitans (Aa) abundance in saliva and subgingival biofilm, and lower levels of INF-ɣ, IL-4, and IL-17 in GCF. Placebo therapy only reduced PI in both groups. Triclosan toothpaste reduced PI and GI in both groups. Triclosan promoted reduction of BoP and probing depth (PD), Aa salivary, and IL-1β levels in AgP group. In health group, triclosan reduced INF-ɣ and IL-4 concentration. CONCLUSION Triclosan toothpaste demonstrated to be more effective than placebo toothpaste to control the periodontal condition in children from AgP parents, by reducing the BoP, PD, salivary Aa, and IL-1β. CLINICAL RELEVANCE Triclosan toothpaste can improve oral conditions in higher-risk population for AgP. TRIAL REGISTRATION This study was registered at ClinicalTrials.gov with the identifier NCT03642353.

中文翻译：

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三氯生牙膏作为牙周炎家庭儿童斑块控制的辅助疗法：一项交叉临床试验。

目的研究表明，来自侵略性牙周炎（AgP）父母的孩子的牙周状况出现了早熟性改变，因此使用化学药剂控制斑块可能有助于控制这些改变。这项研究旨在评估三氯生牙膏对AgP父母儿童的临床和龈下状况的调节作用。方法该交叉安慰剂研究包括15名来自AgP父母的孩子和15名来自牙周健康父母的孩子。使用选定的牙膏将儿童随机分配到三氯生或安慰剂治疗中45天。洗净15天后，将各组交叉放置，更换用过的牙膏。临床检查和唾液，龈沟液（GCF），在每个阶段的基线和45天进行牙龈下生物膜收集。通过Luminex / MAGpix平台分析GCF细胞因子水平，并通过qPCR分析牙龈下和唾液牙周病原体水平。结果在基线时，AgP组表现出较高的斑块指数（PI），牙龈指数（GI）和探查出血（BoP），唾液和龈下生物膜中的聚集性放线菌数量增多（Aa）较高，以及INF-ɣ，IL的水平较低-4和GCF中的IL-17。安慰剂疗法仅能降低两组的PI。三氯生牙膏可降低两组的PI和GI。三氯生可促进AgP组BoP和探测深度（PD），唾液Aa分泌和IL-1β水平降低。在健康组中，三氯生降低了INF-ɣ和IL-4的浓度。结论三氯生牙膏通过减少BoP，PD，唾液Aa和IL-1β，在控制AgP父母患儿的牙周状况方面比安慰剂牙膏更有效。临床意义三氯生牙膏可改善高危人群中AgP的口腔状况。试验注册本研究已在ClinicalTrials.gov上注册，标识为NCT03642353。